Epithalon (Epitalon)
Synthetic tetrapeptide (Ala-Glu-Asp-Gly) based on the pineal gland peptide epithalamin. Activates telomerase reverse transcriptase (hTERT) in somatic cells, elongating telomeres. Regulates melatonin production and circadian rhythm. In rodent studies, extended lifespan and reduced tumor incidence.
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- active-cancer
- leukemia
- PMID:12937225Peptide bioregulation of aging: results of a 15-year follow-up — Bull Exp Biol Med, 2003
- PMID:16714882Effect of epithalon on telomerase activity and telomere length in human somatic cells — Bull Exp Biol Med, 2004
Epithalon activates the enzyme that lengthens telomeres. Telomere shortening correlates with aging. Therefore epithalon slows aging. The logic is seductive, the rodent lifespan data is compelling, and the human evidence is nearly nonexistent. Vladimir Khavinson's research program produced intriguing results but almost entirely in Russian-language journals with small sample sizes. Telomerase activation also has a theoretical cancer concern — cancer cells use telomerase to achieve immortality. The risk-benefit calculation requires honest acknowledgment that both sides of the equation are poorly quantified.
This is not medical advice
Discuss with a licensed clinician before starting, stopping, or changing any compound. This page documents what the research literature describes — it is not a prescription.
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