94 compounds.
Cited, tiered, dose-specific.
Every entry carries mechanism, half-life, bioavailability, three-tier dosing, monitoring labs, contraindications, and PubMed references. The library that routes into every OPTIMIZE protocol — browsable here without signing in.
Testosterone 101
11 · ~25 minThe full T-optimization arc — natural levers first, then TRT + ancillaries, then peptide + SARM discussion.
Sleep — deep dive
7 · ~18 minFrom magnesium + glycine foundations to apigenin, melatonin timing, and the controversial tier (ashwagandha at night, low-dose trazodone).
Peptides — the honest intro
7 · ~20 minRegulatory status first, mechanism second. BPC-157, TB-500, and GH secretagogue stacks — what the evidence actually says.
GLP-1 basics
6 · ~15 minSemaglutide vs tirzepatide vs liraglutide. Titration, monitoring, lean-mass preservation. What Mochi doesn't tell you.
Senolytics + longevity foundations
8 · ~22 minFisetin, quercetin, spermidine, NMN, urolithin A. mTOR modulators next (rapamycin, metformin). The Attia-Sinclair reading list.
Cognition stack
8 · ~18 minEvidence-first nootropics. Creatine, omega-3, caffeine + L-theanine, alpha-GPC. Racetam + peptide tier last.
- T39-MBC (9-Methyl-beta-carboline)t½ Not characterized in humans
- T1Alpha-GPC (L-Alpha Glycerylphosphorylcholine)t½ 4-6 hours
- T2Aniracetamt½ 1-2.5 hours
- T1Ashwagandha KSM-66t½ 6-12 hours (withanolides)
- T1Bacopa Monnierit½ 2-6 hours (bacosides)
- T1CDP-Choline (Citicoline)t½ 56 hours (cytidine component)
- T1Cerebrolysint½ Minutes to hours (individual peptide fragments vary)
- T2Cortexint½ Not fully characterized (peptide mixture)
- T3Fasoracetam (NFC-1 / NS-105)t½ 1.5-2 hours (estimated from Phase I data)
- T1L-Theaninet½ 1-2 hours (plasma), functional effects persist 4-6 hours
- T2Lion's Mane (Hericium erinaceus)t½ Not well characterized (bioactive terpenoids)
- T2Noopept (GVS-111)t½ 30-60 minutes (parent compound, active metabolites persist longer)
- T3NSI-189 (Phosphate)t½ 6-10 hours (estimated from Phase I PK data)
- T1Piracetamt½ 5 hours
- T1Rhodiola Roseat½ 6-8 hours (salidroside)
- T3AOD-9604t½ Variable (limited pharmacokinetic data)
- T2BPC-157t½ 2 hours
- T2CJC-1295 no DAC (Mod GRF 1-29)t½ 30 minutes
- T2CJC-1295 with DACt½ 8 days
- T3Dihexat½ Poorly characterized
- T3Epithalon (Epitalon)t½ Poorly characterized (short peptide, likely minutes)
- T2GHK-Cut½ Topical — local depot effect; systemic half-life poorly characterized
- T2GHRP-2t½ 15-60 minutes
- T2GHRP-6t½ 15-60 minutes
- T2Hexarelint½ 70 minutes
- T2Ipamorelint½ 2 hours
- T3KPVt½ Short (tripeptide, rapid degradation)
- T3LL-37t½ Poorly characterized systemically (local tissue persistence)
- T1MK-677 (Ibutamoren)t½ 4-6 hours (functional GH elevation lasts 24 hours)
- T2MOTS-ct½ 4 hours (estimated)
- T3PE-22-28t½ Poorly characterized
- T1PT-141 (Bremelanotide)t½ 2.7 hours
- T2Selankt½ Several minutes (nasal), extended by Pro-Gly-Pro stabilization
- T2Semaxt½ Several minutes (extended by Pro-Gly-Pro stabilization)
- T1Sermorelint½ 10-20 minutes
- T2SS-31 (Elamipretide)t½ 4 hours
- T2TB-500 (Thymosin Beta-4)t½ 2 hours
- T1Tesamorelint½ 26 minutes (IV), extended subcutaneous absorption
- T3Thymalint½ Poorly characterized
- T1Thymosin Alpha-1t½ 2 hours
- T1Acarboset½ 2 hours
- T1Armodafinilt½ 15 hours
- T1Doxazosint½ 22 hours
- T1Dutasteridet½ 5 weeks
- T2Enclomiphenet½ 10 hours
- T1Finasteridet½ 6-8 hours
- T2Low-Dose Naltrexone (LDN)t½ 4 hours
- T1Metformint½ 6.2 hours
- T2Minoxidil (Oral)t½ 4.2 hours
- T1Modafinilt½ 15 hours
- T1Nebivololt½ 12-19 hours
- T2Pentoxifyllinet½ 0.4-0.8 hours (active metabolites 1-1.6 hours)
- T1Pioglitazonet½ 3-7 hours (active metabolites 16-24 hours)
- T2Rapamycin (Sirolimus)t½ 62 hours
- T1Sildenafilt½ 4 hours
- T1Tadalafilt½ 17.5 hours
- T1Telmisartant½ 24 hours
- T1Dasatinib (Sprycel)t½ 3-5 hours
- T2Fisetint½ ~2 hours
- T2GlyNAC (Glycine + N-Acetyl Cysteine)t½ ~6 hours (combined effective half-life, NAC ~5.6hr, glycine ~4hr)
- T3Navitoclax (ABT-263)t½ 8 hours
- T2NMN (Nicotinamide Mononucleotide)t½ ~3 hours
- T2Rapamycin (Sirolimus)t½ 62 hours
- T2Resveratrolt½ 1-3 hours (parent compound), 9.2 hours (metabolites)
- T2Spermidinet½ Variable (rapidly metabolized and incorporated into polyamine pools)
- T1Acetyl-L-Carnitine (ALCAR)t½ ~4.2 hours
- T1Ashwagandha (Sensoril)t½ ~6 hours (estimated from PK data of withanolide A)
- T1Berberinet½ ~5 hours
- T2Citrus Bergamot Extractt½ ~6 hours (estimated from polyphenol PK)
- T1Coenzyme Q10 (Ubiquinone/Ubiquinol)t½ ~33 hours
- T1Creatine Monohydratet½ ~3 hours (plasma)
- T2Fisetint½ ~2 hours
- T1Fish Oil (EPA/DHA)t½ ~50 hours (EPA/DHA in plasma phospholipids)
- T1N-Acetyl Cysteine (NAC)t½ ~6.25 hours
- T2Nicotinamide Mononucleotide (NMN)t½ ~3 hours (plasma)
- T2Pyrroloquinoline Quinone (PQQ)t½ ~5 hours
- T1Quercetint½ ~11 hours
- T2Tauroursodeoxycholic Acid (TUDCA)t½ ~4 hours (estimated)
- T2Tongkat Ali (Eurycoma longifolia)t½ ~9 hours (estimated from eurycomanone PK)
- T1Vitamin D3 + K2 (MK-7)t½ ~15 days (25(OH)D); ~72 hours (MK-7)
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