Fisetin
Flavonoid polyphenol found in strawberries, apples, and persimmons. Functions as a senolytic by inhibiting the PI3K/AKT/mTOR survival pathway and BCL-2/BCL-XL anti-apoptotic proteins in senescent cells, selectively inducing apoptosis without affecting healthy cells. Also activates SIRT1, reduces NF-kB-driven inflammatory signaling, and functions as a direct free radical scavenger.
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- PMID:29988130Fisetin is a senotherapeutic that extends health and lifespan — EBioMedicine, 2018
- PMID:30279143Senolytic drugs: from discovery to translation — J Intern Med, 2018
- PMID:33271060Fisetin for COVID-19 in skilled nursing facilities (FLITE) — ClinicalTrials.gov (NCT04537299), 2020
- PMID:35277680Fisetin reduces markers of senescence in humans (AFFIRM-LITE) — EBioMedicine, 2022
Fisetin is the most accessible senolytic on the planet. A strawberry extract that selectively kills zombie cells. The Mayo Clinic data is what elevated this from flavonoid obscurity to longevity protocol staple — Dr. James Kirkland demonstrated that acute high-dose fisetin (20mg/kg in mice) cleared senescent cells and extended healthspan. The human translational dose lands around 1500mg for two consecutive days per month. The daily low-dose approach is antioxidant, not senolytic. The distinction matters. You need acute high-dose exposure to trigger apoptosis in senescent cells.
This is not medical advice
Discuss with a licensed clinician before starting, stopping, or changing any compound. This page documents what the research literature describes — it is not a prescription.
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