GHK-Cu
Naturally occurring copper-binding tripeptide (glycyl-L-histidyl-L-lysine) that declines with age. Activates tissue remodeling via metalloproteinase regulation, stimulates collagen and glycosaminoglycan synthesis, and attracts immune cells for repair. Modulates over 4,000 genes — suppressing fibrinogen and inflammatory markers while upregulating growth factors.
Three tiers ordered by aggressiveness. Tier chips on every OPTIMIZE intervention let you filter the catalog by your evidence tolerance.
- hs-crp
- iron-panel
- copper-sensitivity
- wilsons-disease
- PMID:24508075GHK peptide as a natural modulator of multiple cellular pathways in skin regeneration — Biomed Res Int, 2014
- PMID:20886903The human tripeptide GHK-Cu in prevention of oxidative stress and degenerative conditions — Oxid Med Cell Longev, 2012
GHK-Cu is the remodeling signal. Not growth. Not repair. Remodeling — the coordinated demolition and reconstruction of tissue architecture. The gene expression data is staggering in breadth. Over 4,000 genes modulated. The copper ion is not decoration. It is the catalytic center that drives metalloproteinase activity. Your body produces this peptide naturally and produces less of it every decade after 20. The topical applications have the most consumer data. The systemic applications have the most interesting mechanistic potential.
This is not medical advice
Discuss with a licensed clinician before starting, stopping, or changing any compound. This page documents what the research literature describes — it is not a prescription.
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