Hexarelin
Synthetic hexapeptide growth hormone secretagogue with high potency at GHS-R1a. Produces strong GH pulse comparable to GHRP-2 but desensitizes the receptor within 4-8 weeks of continuous use. Notable cardiac protective effects independent of GH — direct binding to cardiac CD36 receptors.
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- active-cancer
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- PMID:10721907Hexarelin, a synthetic growth hormone secretagogue: cardioprotective effects — Pharmacol Res, 2000
- PMID:10372583Desensitization and recovery of growth hormone response to hexarelin — Growth Horm IGF Res, 1999
Hexarelin has the most interesting secondary pharmacology of any GH secretagogue. The cardiac CD36 binding is completely independent of growth hormone — it protects cardiomyocytes directly. But the receptor desensitization is the dealbreaker for long-term use. After 4-8 weeks, the GH response fades. You must cycle off. This makes hexarelin a burst tool, not a foundation compound. The cardiac data is why some researchers keep studying it despite the desensitization ceiling.
This is not medical advice
Discuss with a licensed clinician before starting, stopping, or changing any compound. This page documents what the research literature describes — it is not a prescription.
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