Ipamorelin
Selective ghrelin receptor (GHS-R1a) agonist. Stimulates pituitary GH release without significantly elevating cortisol, prolactin, or ACTH — unique selectivity among growth hormone secretagogues. Does not produce appetite stimulation at standard doses. Synergistic with GHRH analogs.
Three tiers ordered by aggressiveness. Tier chips on every OPTIMIZE intervention let you filter the catalog by your evidence tolerance.
- igf-1
- fasting-glucose
- cortisol
- active-cancer
- pituitary-tumor
- PMID:9849822Ipamorelin, the first selective growth hormone secretagogue — Eur J Endocrinol, 1998
- PMID:10372583Safety and tolerability of ipamorelin in healthy volunteers — Growth Horm IGF Res, 1999
Ipamorelin is the cleanest GH secretagogue. No cortisol spike. No prolactin elevation. No appetite surge. That selectivity profile is why it became the default pairing with Mod GRF 1-29. The two peptides hit different receptors on the same cell — GHRH receptor and ghrelin receptor — producing additive GH output without additive side effects. If you are building a GH peptide stack, this is the foundation compound.
This is not medical advice
Discuss with a licensed clinician before starting, stopping, or changing any compound. This page documents what the research literature describes — it is not a prescription.
See Ipamorelin in a protocol matched to you