Compound · pe-22-28
T3Peptide

PE-22-28

Synthetic heptapeptide analog of spadin. Blocks TREK-1 potassium channels, which are involved in serotonin neurotransmission regulation. TREK-1 deletion in mice produces an antidepressant phenotype. PE-22-28 mimics this effect pharmacologically, acting as a rapid-onset antidepressant in rodent models without SSRI lag time.

Half-life
Poorly characterized
Bioavailability
Subcutaneous; intranasal (limited data)
Route
subcutaneous, intranasal
Evidence tier
T3 — Community / emerging
Optimization pillars
recovery
References
2 peer-reviewed
Dose ranges

Three tiers ordered by aggressiveness. Tier chips on every OPTIMIZE intervention let you filter the catalog by your evidence tolerance.

conservative
50–100 mcg/day
Mood support
moderate
100–300 mcg/day
Antidepressant-like protocol
aggressive
300–500 mcg/day
Experimental (no human dosing data)
Monitoring
  • cortisol
Contraindications
  • pregnancy
  • bipolar-disorder
  • seizure-disorders
References
  • PMID:23954677PE 22-28, a spadin analog, acts as an antidepressant by blocking TREK-1 channelBr J Pharmacol, 2013
  • PMID:19913560A new antidepressant drug candidate: spadin and TREK-1Pharmacol Ther, 2010
Notes

PE-22-28 targets a mechanism that SSRIs do not touch. TREK-1 potassium channels modulate serotonin neuron excitability. Blocking them produces antidepressant behavior in mice within 4 days — compared to 3-4 weeks for SSRIs. The speed of onset is the theoretical advantage. The practical limitation is complete. Zero human data. Zero established dosing. Zero safety profile outside of rodent toxicology. The mechanism is novel and the preclinical data is consistent. That is all you can honestly say about it.

This is not medical advice

Discuss with a licensed clinician before starting, stopping, or changing any compound. This page documents what the research literature describes — it is not a prescription.

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