Semax
Synthetic analog of ACTH fragment 4-10 with a Pro-Gly-Pro C-terminal extension. Enhances BDNF and TrkB expression, modulates dopaminergic and serotonergic systems, and provides neuroprotection via suppression of nitric oxide overproduction. Approved in Russia for stroke recovery and cognitive enhancement.
Three tiers ordered by aggressiveness. Tier chips on every OPTIMIZE intervention let you filter the catalog by your evidence tolerance.
- cortisol
- thyroid-panel
- pregnancy
- seizure-disorders
- acute-psychosis
- PMID:17369778Semax, an analog of ACTH(4-10), regulates expression of immune response genes — Bull Exp Biol Med, 2006
- PMID:16996037Nootropic and analgesic effects of Semax following different routes of administration — Regul Pept, 2006
Semax is the cognitive peptide with stroke-recovery origins. The Russian clinical data is extensive but poorly translated into Western clinical frameworks. The BDNF upregulation is the same mechanism that makes exercise neuroprotective — except delivered as a nasal spray. The ACTH fragment origin raises cortisol questions, but at clinical doses, adrenal stimulation is negligible. Semax and Selank are frequently stacked. Different receptor targets, complementary cognitive and anxiolytic profiles.
This is not medical advice
Discuss with a licensed clinician before starting, stopping, or changing any compound. This page documents what the research literature describes — it is not a prescription.
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