Sermorelin
Synthetic analog of the first 29 amino acids of endogenous GHRH. Stimulates physiological pulsatile GH release from the anterior pituitary. FDA-approved for diagnosis and treatment of growth hormone deficiency in children. Preserves the hypothalamic-pituitary feedback loop.
Three tiers ordered by aggressiveness. Tier chips on every OPTIMIZE intervention let you filter the catalog by your evidence tolerance.
- igf-1
- fasting-glucose
- fasting-insulin
- active-cancer
- pituitary-tumor
- PMID:9467534Sermorelin: a review of its pharmacology and clinical use — Clin Pharm, 1997
- PMID:12172220Effects of sermorelin on sleep quality and nocturnal growth hormone secretion — Neuroendocrinology, 2002
Sermorelin is the original GH peptide. FDA-approved. Well-characterized pharmacology. The reason newer peptides like Mod GRF 1-29 exist is that sermorelin degrades quickly — the amino acid substitutions in Mod GRF extend stability. But sermorelin has something the newer analogs do not. Regulatory approval and decades of safety data. For the risk-conscious user, the proven track record has value that novelty does not.
This is not medical advice
Discuss with a licensed clinician before starting, stopping, or changing any compound. This page documents what the research literature describes — it is not a prescription.
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