GLP-1 basics
Semaglutide vs tirzepatide vs liraglutide. Titration, monitoring, lean-mass preservation. What Mochi doesn't tell you.
- 01Semaglutidet½ 7 days (168 hours)
Acylated GLP-1 receptor agonist with 94% homology to native GLP-1. Binds the GLP-1 receptor on pancreatic beta cells, enhancing glucose-dependent insulin secretion while suppressin…
- 02Tirzepatidet½ 5 days (120 hours)
Dual GIP and GLP-1 receptor agonist built on a 39-amino acid synthetic peptide backbone. Activates both incretin pathways simultaneously — GLP-1R for appetite suppression and insul…
- 03Liraglutidet½ 13 hours
Acylated GLP-1 analog with 97% homology to native human GLP-1. The C16 fatty acid chain enables albumin binding, extending duration from the native peptide’s 2-minute half-life to …
- 04Retatrutidet½ ~5 days (~120 hours, estimated from phase 2 PK data)
Triple agonist targeting GLP-1, GIP, and glucagon receptors simultaneously. The glucagon receptor activation adds a thermogenic and lipolytic dimension absent from dual agonists — …
- 05Metformint½ 6.2 hours
Activates AMPK via inhibition of mitochondrial complex I, reducing hepatic glucose output and improving peripheral insulin sensitivity. Secondary effects include suppression of mTO…
- 06Berberinet½ ~5 hours
Isoquinoline alkaloid that activates AMP-activated protein kinase (AMPK) in liver, muscle, and adipose tissue. AMPK activation improves insulin sensitivity by increasing GLUT4 tran…
Ready to run a protocol?
OPTIMIZE builds a personalized protocol that routes these compounds for you — filtered by your intake, evidence tolerance, and goals.
Build my protocol