Cognition stack
Evidence-first nootropics. Creatine, omega-3, caffeine + L-theanine, alpha-GPC. Racetam + peptide tier last.
- 01creatine — entry pending
- 02omega-3-fish-oil — entry pending
- 03L-Theaninet½ 1-2 hours (plasma), functional effects persist 4-6 hours
Non-proteinogenic amino acid structurally analogous to glutamate. Crosses the blood-brain barrier via the leucine-preferring transport system. Increases alpha-wave activity (8-13 H…
- 04Alpha-GPC (L-Alpha Glycerylphosphorylcholine)t½ 4-6 hours
Bioavailable choline source that crosses the blood-brain barrier efficiently. Serves as a direct precursor to acetylcholine synthesis via choline acetyltransferase. Also acts as a …
- 05Lion's Mane (Hericium erinaceus)t½ Not well characterized (bioactive terpenoids)
Medicinal mushroom containing hericenones (fruiting body) and erinacines (mycelium), which cross the blood-brain barrier and stimulate nerve growth factor (NGF) synthesis via the T…
- 06Bacopa Monnierit½ 2-6 hours (bacosides)
Steroidal saponins called bacosides (primarily bacoside A and B) modulate serotonergic, dopaminergic, and cholinergic neurotransmission simultaneously. Upregulates tryptophan hydro…
- 07Rhodiola Roseat½ 6-8 hours (salidroside)
Adaptogenic herb whose primary bioactive, salidroside, inhibits monoamine oxidase (MAO-A and MAO-B), increasing synaptic availability of serotonin, dopamine, and norepinephrine. Mo…
- 08Modafinilt½ 15 hours
Weak dopamine transporter (DAT) inhibitor that elevates synaptic dopamine, with secondary activation of orexin/hypocretin neurons in the lateral hypothalamus. Also modulates norepi…
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