Peptides — the honest intro
Regulatory status first, mechanism second. BPC-157, TB-500, and GH secretagogue stacks — what the evidence actually says.
- 01BPC-157t½ 2 hours
Gastric pentadecapeptide derived from human gastric juice. Upregulates growth hormone receptors, promotes angiogenesis via VEGF, and modulates nitric oxide signaling. Accelerates t…
- 02TB-500 (Thymosin Beta-4)t½ 2 hours
43-amino acid peptide identical to endogenous thymosin beta-4. Sequesters G-actin monomers, promoting cell migration and tissue repair. Upregulates actin polymerization, driving wo…
- 03cjc-1295 — entry pending
- 04Ipamorelint½ 2 hours
Selective ghrelin receptor (GHS-R1a) agonist. Stimulates pituitary GH release without significantly elevating cortisol, prolactin, or ACTH — unique selectivity among growth hormone…
- 05Sermorelint½ 10-20 minutes
Synthetic analog of the first 29 amino acids of endogenous GHRH. Stimulates physiological pulsatile GH release from the anterior pituitary. FDA-approved for diagnosis and treatment…
- 06Tesamorelint½ 26 minutes (IV), extended subcutaneous absorption
Synthetic analog of GHRH with a trans-3-hexenoic acid modification. FDA-approved for HIV-associated lipodystrophy. Stimulates pulsatile GH release and reduces visceral adipose tiss…
- 07GHK-Cut½ Topical — local depot effect; systemic half-life poorly characterized
Naturally occurring copper-binding tripeptide (glycyl-L-histidyl-L-lysine) that declines with age. Activates tissue remodeling via metalloproteinase regulation, stimulates collagen…
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